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  6. 16086276

CD46, Mouse, PE, Clone: MEM-258, Abnova™

Mouse monoclonal antibody raised against native CD46.

Brand:  Abnova MAB4442.100Reactions

Product Code. 16086276

  • € 388.00 / 100 reactions

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Description

Description

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq

Specifications

Specifications

CD46
Monoclonal
PE
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user.
CD46
CD46
Native purified CD46 from human T cell line HPB-ALL.
RUO
4179
Bovine, Human
Liquid
Flow Cytometry, Immunoprecipitation, Western Blot
MEM-258
Mouse monoclonal antibody raised against native CD46.
In PBS (0.2% BSA, 0.09% sodium azide)
MCP/MGC26544/MIC10/TLX/TRA2.10
Mouse
100 Reactions
Primary
This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 KDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
IgG1
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