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ITGB2, Mouse, APC, Clone: MEM-48, Abnova™

Product Code. 16076376
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100 Reactions
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100 reactions
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16076376 100 Reactions 100 reactions
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Product Code. 16076376 Supplier Abnova Supplier No. MAB4592.100Reactions

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Description

Mouse monoclonal antibody raised against native ITGB2.

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq

Specifications

Antigen ITGB2
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-48
Conjugate APC
Description Mouse monoclonal antibody raised against native ITGB2.
Dilution Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.2% BSA, 0.09% sodium azide)
Gene ITGB2
Gene Alias CD18/LAD/LCAMB/LFA-1/MAC-1/MF17/MFI7
Gene Symbols ITGB2
Host Species Mouse
Immunogen Native purified ITGB2 from leukocytes of patient suffering from LGL-type leukaemia.
Quantity 100 Reactions
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3689
Test Specificity This antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta 2 subunit; beta 2 integrin). CD18 is a 90-95 KDa type I transmembrane protein expressed on all leukocytes.
Target Species Human
Content And Storage Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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