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  6. 16169799

MSR1, Mouse, Clone: SRA-E5, Abnova™

Mouse monoclonal antibody raised against recombinant MSR1.

Brand:  Abnova MAB1710.50ug

Product Code. 16169799

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Description

Description

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq]

Specifications

Specifications

MSR1
Monoclonal
Unconjugated
Immunohistochemistry (10 ug/mL) Western Blot (2 ug/mL) The optimal working dilution should be determined by the end user.
MSR1
MSR1
Recombinant protein corresponding to human MSR1.
RUO
4481
Liquid
Immunohistochemistry, Western Blot
SRA-E5
Mouse monoclonal antibody raised against recombinant MSR1.
In PBS (0.1% proclin, 2.0% Block Ace)
CD204/SCARA1/SR-A/phSR1/phSR2
Mouse
50 μg
Primary
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
IgG1
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