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NCF4, Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a partial recombinant NCF4.

Brand:  Abnova H00004689-A01.50uL

Product Code. 16181695

  • € 242.00 / 50µL

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Description

Description

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

Sequence: MAVAQQLRAESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQE
Specifications

Specifications

NCF4
Polyclonal
Mouse polyclonal antibody raised against a partial recombinant NCF4.
NCF4
MGC3810/NCF/P40PHOX/SH3PXD4
Mouse
50 μL
Primary
Human
Antisera
ELISA, Western Blot
Unconjugated
50% glycerol
BC002798
NCF4
NCF4 (AAH02798, 1 a.a. ∽ 100 a.a) partial recombinant protein with GST tag.
RUO
4689
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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