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Proteintech™ Mouse IL-21 ELISA Kit
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Target Species:
Mouse
Unit Size:
96 tests
Description
- The assay recognizes mouse IL21. An antibody specific for mouse IL21 has been pre-coated onto the microwells.
- The mouse IL21 protein in samples is captured by the coated antibody after incubation.
- Following extensive washing, another antibody of biotinylated specific for mouse IL21 is added to detect the captured mouse IL21 protein.
- For signal development, Streptavidin-HRP is added, followed by Tetramethyl-benzidine (TMB) reagent.
- Solution containing sulfuric acid is used to stop color development and the color intensity which is proportional to the quantity of bound protein is measurable at 450nm with the correction wavelength set at 630 nm.
- Interleukin 21 (IL21) is a cytokine produced predominantly by cluster of differentiation 4 (CD4+) T-cells and natural killer T-cells.
- IL21 is preliminarily expressed in activated cluster of differentiation 4 (CD4+) T-cells and natural killer (NK) T-cells. IL21 receptor (il21R) is a class I cytokine receptor, which requires dimerization with the indispensable common gamma chain (γc) subunit to bind IL21.
- IL21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells.
- IL21 mediates apoptosis in B-CLL cells through up-regulation of the BIM (BH3 family member) and enhances both direct and antibody-dependent cellular cytotoxicity in these cells.
Specifications
Specifications
| Accession Number | NP_068554 |
| Assay Range | 15.6 to 1000 pg/mL |
| Assay Sensitivity | 0.5 pg/mL |
| Certifications/Compliance | ISO 13485 |
| Detection Method | Sandwich ELISA, Double Antibody |
| Immunoassay Kit Format | Coated ELISA Kit |
| Sample Type | Plasma, Serum |
| Substrate | DAB |
| Target Species | Mouse |
| Gene ID (Entrez) | 60505 |
| Show More |
Safety and Handling
Product Identifier
- 96TEST Mouse IL-21 ELISA Kit
- Warning
- Serious eye damage/eye irritation Category 1
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
- H302-Harmful if swallowed.
- H315-Causes skin irritation.
- H318-Causes serious eye damage.
- H319-Causes serious eye irritation.
- H332-Harmful if inhaled.
- H335-May cause respiratory irritation.
- P201-Obtain special instructions before use.
- P202-Do not handle until all safety precautions have been read and understood.
- P234-Keep only in original container.
- P264-Wash skin thoroughly after handling.
- P270-Do not eat, drink or smoke when using this product.
- P273-Avoid release to the environment.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P308+P313-IF exposed or concerned: Get medical advice/attention.
- P330-Rinse mouth.
- P362-Take off contaminated clothing.
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : Sulphuric Acid, Tetramethylbenzidine
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