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Invitrogen™ Mouse PD-L1 (B7-H1) His-tag Recombinant Protein

Product Code. 17995731
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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17995731 1 mg 1mg
17986511 100 μg 100µg
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Product Code. 17995731 Supplier Invitrogen™ Supplier No. RP88254

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Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (400 μL) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV.

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9EP73
Concentration 0.25 mg/mL
For Use With (Application) Control, ELISA Standard, Binding Assay
Format Lyophilized
Formulation PBS with 5% mannitol, 5% trehalose and no preservative; pH 7.4
Gene ID (Entrez) 60533
Molecular Weight (g/mol) 26.21 kDa
Name Mouse PD-L1 (B7-H1) His-tag
pH Range 7.4
Purification Method Purified
Quantity 1 mg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Common Name PD-L1 (CD274)
Gene Symbol Cd274
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-L1 (at 1 μg/ml (100 μL/well) can bind mouse PD1 with a linear range of 6.25-400 ng/mL)
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag His-tag
Sequence Mouse PD-L1, amino acids Met1-Thr238 (Accession # NP_068693.1) with a C-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-L1 at 1 μg/ml (100 μL/well) can bind mouse PD1 with a linear range of 6.25-400 ng/mL.
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade >98% as determined by SDS-PAGE.
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