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Invitrogen™ MRC2 Polyclonal Antibody
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Product Code. 16540102
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Quantity:
100 μL
Unit Size:
100µL
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16540102 100 μL 100µL
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Product Code. 16540102 Supplier Invitrogen™ Supplier No. PA597268

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RWHCRTLGDQ LSLLLGARTS NISKPGTLER GDQTRSGQWR IYGSEEDLCA LPYHEVYTIQ GNSHGKPCTI PFKYDNQWFH GCTSTGREDG HLWCATTQDY GKDERWGFCP IKSNDCETFW DKDQLTDSCY QFNFQSTLSW REAWASCEQQ GADLLSITEI HEQTYINGLL TGYSSTLWIG L; Positive Samples: SH-SY5Y, HeLa, Mouse kidney; Cellular Location: Membrane, Single-pass type I membrane protein.

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
TRUSTED_SUSTAINABILITY

Specifications

Antigen MRC2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MRC2
Gene Accession No. Q64449, Q9UBG0
Gene Alias CD280; CLEC13E; collagen-binding factor Endo180; C-type lectin domain family 13 member E; C-type mannose receptor 2; Endo180; endocytic receptor (macrophage mannose receptor family); endocytic receptor 180; KIAA0709; Lectin lambda; macrophage mannose receptor 2; mannose receptor C type 2; mannose receptor, C type 2; mKIAA0709; Mrc2; novel lectin; UPARAP; UPAR-associated protein; urokinase-type plasminogen activator receptor-associated protein
Gene Symbols MRC2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_0060302).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17534, 9902
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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