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Invitrogen™ N4BP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA559323
This item is not returnable.
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Description
Immunogen sequence: NELTTDSTPK KTQAHTQQNM VEKFSQLPFK VEAKPCTSNC RINTFRTVPI EQKHEVWGSN QNYICNTDPE TDGLSPSVAS PSPKEVNFVS RGASSHQPR Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 67%.
Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
Specifications
| N4BP1 | |
| Polyclonal | |
| Unconjugated | |
| N4BP1 | |
| AI481586; C81621; Kiaa0615; N4BP1; Nedd4 binding protein 1; NEDD4-binding protein 1; RGD1305179 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 9683 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| O75113 | |
| N4BP1 | |
| Recombinant protein corresponding to Human N4BP1. Recombinant protein control fragment (Product #RP-98671). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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