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Invitrogen™ NALP12 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5143098
This item is not returnable.
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Description
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Specifications
| NALP12 | |
| Polyclonal | |
| Unconjugated | |
| NLRP12 | |
| CLR19.3; FCAS2; monarch 1; monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NALP12; NLR family pyrin domain containing 12; NLR family, pyrin domain containing 12; Nlrp12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; RNO; RNO2 | |
| Goat | |
| Ammonium sulfate precipitation | |
| RUO | |
| 378425 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.5 mg/mL | |
| TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
| E9Q5R7 | |
| NLRP12 | |
| Peptide with sequence C-DDPPEPSGVQTQST. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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