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Invitrogen™ NALP7 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584063

Product Code. 16361015

  • € 560.00 / 100µL

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Description

Description

Immunogen sequence: LNEDELKSFK SLLWAFPLED VLQKTPWSEV EEADGKKLAE ILVNTSSENW IRNATVNILE EMNLTELCKM AK Highest antigen sequence indentity to the following orthologs: Rat - 33%, Mouse - 35%.

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1-b secretion and is a feedback regulator of interleukin-1-b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NALP7
Polyclonal
Unconjugated
NLRP7
CLR19.4; HYDM; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NALP7; NLR family pyrin domain containing 7; NLR family, pyrin domain containing 7; NLRP7; NOD12; Nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing APAF1-like protein 3
Rabbit
Antigen affinity chromatography
RUO
199713
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin)
0.2 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q8WX94
NLRP7
Recombinant protein corresponding to Human NLRP7. Recombinant protein control fragment (Product #RP-99144).
100 μL
Primary
Human
Antibody
IgG
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