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  6. Nanog Mouse anti-Human, PE, Clone: N31-355, BD

Nanog Mouse anti-Human, PE, Clone: N31-355, BD

Mouse Monoclonal Antibody

€ 164.35 - € 304.95

Specifications

Antigen Nanog
Clone N31-355
Applications Flow Cytometry
Classification Monoclonal
Conjugate PE
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BD Biosciences
560873 		25 Tests
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BD Biosciences
560483 		100 Tests
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Description

Description

The N31-355 monoclonal antibody reacts with human Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone Morphogenic Protein). When Nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53. Nanog is one of the factors that can contribute to reprogramming of differentiated cells to an induced pluripotent stem cell state.

Specifications

Specifications

Nanog
Flow Cytometry
PE
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
N31-355
Monoclonal
Mouse
Human
Human Nanog Recombinant Protein
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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