Invitrogen™ NAV3 Polyclonal Antibody

Description

Immunogen sequence: STDDLNTTSS VSSYSNITVP SRKNTQLRTD SEKRSTTDET WDSPEELKKP EEDFDSHGDA GGKWKTVSSG LPEDPEKAGQ KASLS Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

Neuron navigator 3 (NAV3), also known as pore membrane and/or filamentinteracting-like protein 1 (POMFIL1), unc-53 homolog 3 (unc53H3) or STEERIN3, is a 2,385 amino acid protein that localizes to the nuclear outer membrane and plays a role in neuron regeneration. Existing as three alternatively spliced isoforms, Neuron navigator 3 is highly expressed in adult and fetal brain and is found at moderate to low levels in ovary, lung, testis, placenta and heart. Neuron navigator 3 is thought be involved in the regulation of IL-2 production and contains one CH (calponin-homology) domain, three N-terminal hydrophobic domains, multiple N-glycosylation sites, three ATP/GTP-binding A motifs (P loops) and several phosphorylation sites.