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Invitrogen™ NCF4 Polyclonal Antibody
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Product Code. 11306733
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Quantity:
100 μg
Unit Size:
100µg
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11306733 100 μg 100µg
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Product Code. 11306733 Supplier Invitrogen™ Supplier No. PA518751

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Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NCF4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Ncf4
Gene Accession No. Q15080
Gene Alias AI451400; CGD3; CTA-833B7.1; MGC3810; NCF; Ncf4; NCF-4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; neutrophil NADPH oxidase factor 4; OTTHUMP00000028736; OTTHUMP00000043756; P40PHOX; p40-phox; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Symbols Ncf4
Host Species Goat
Immunogen Synthetic peptide sequence (KDFPEEDDPTN) corresponding to the internal amino acids of NCF4 (aa 228-239).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4689
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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