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NCOA4 Monoclonal Antibody (OTI2G10), TrueMAB™, OriGene
Description
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
Specifications
Specifications
| Antigen | NCOA4 |
| Applications | Western Blot |
| Classification | Monoclonal |
| Clone | OTI2G10 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 1% BSA, 50% glycerol and 0.02% sodium azide |
| Gene | NCOA4 |
| Gene Accession No. | Q13772 |
| Gene Alias | ARA70, ELE1, PTC3, RFG |
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Product Title
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