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NCOA4 Monoclonal Antibody (OTI2G10), TrueMAB™, OriGene

Product Code. 17526653
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17526653 100 μL 100µL
17546653 30 μL 30µL
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Product Code. 17526653 Supplier Origene Technologies Supplier No. TA806471

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Mouse Monoclonal Antibody

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion. ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARg in adipocytes. ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.

Specifications

Antigen NCOA4
Applications Western Blot
Classification Monoclonal
Clone OTI2G10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene NCOA4
Gene Accession No. Q13772
Gene Alias ARA70, ELE1, PTC3, RFG
Gene Symbols NCOA4
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 280-553 of human NCOA4 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8031
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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