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Invitrogen™ NDFIP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552657

Product Code. 15710611

  • € 568.00 / 100µL

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Description

Description

Immunogen sequence: AAAGATGSEE LPPGDRGCRN GGGRGPAATT SSTGVAVGAE HGEDSLSRKP DPEPGRMDHH QPGTGRYQVL LNEEDN Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 74%.

Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NDFIP2
Polyclonal
Unconjugated
NDFIP2
0710001O20Rik; 2810436B12Rik; 9130207N19Rik; KIAA1165; MAPK-activating protein PM04 PM05 PM06 PM07; mKIAA1165; N4wbp5a; NDFIP2; Nedd4 family interacting protein 2; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; NF-kappa-B-activating protein 413; putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413; Unknown (protein for IMAGE:7958216); wu:fa92h03; wu:fk31f07; zgc:63948
Rabbit
Antigen Affinity Chromatography
RUO
54602
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9NV92
NDFIP2
Recombinant protein corresponding to Human NDFIP2. Recombinant protein control fragment (Product #RP-89600).
100 μL
Primary
Human
Antibody
IgG
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