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Necrosulfonamide, MedChemExpress

Product Code. 16495817
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Product Code. 16495817 Supplier Medchem Express Supplier No. HY100573

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Description

MedChemExpress Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.

Specifications

Chemical Name or Material Necrosulfonamide
CAS 1360614-48-7
Color Yellow
Purity Grade Notes Research
Molecular Formula C18H15N5O6S2
Quantity 5 mg
Solubility Information DMSO : ≥ 28 mg/mL (60.68 mM)
SMILES O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3.[(E)]
Molecular Weight (g/mol) 461.47
Formula Weight 461.47
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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