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Invitrogen™ NEK3 Polyclonal Antibody
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Product Code. 17137953
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Quantity:
100 μL
Unit Size:
100µL
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17137953 100 μL 100µL
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Product Code. 17137953 Supplier Invitrogen™ Supplier No. PA5110021

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PEIIMEYGEE VLEEIKNSKH NTPRKKTNPS RIRIALGNEA STVQEEEQDR KGSHTDLESI NENLVESALR RVNREEKGNK SVHLRKASSP NLHRRQWEKN VPNTALTALE NASILTSSLT AEDDRGGSVI KYSKNTTRKQ WLKETPDTLL NILKNADLSL AFQTYTIYRP GSEGFLKGPL SEETEASDSV DGGHDSVILD PERLEPGLDE EDTDFEEEDD NPDWVSELKK RAGWQGLCDR.

NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2, Nek3 and Nek4 (also designated STK2 or NRK2). High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Nek3 is a predominantly cytoplasmic enzyme that was detectable in all organs studied. Levels of Nek3 seem to remain unchanged throughout the cell cycle, but appear to be elevated in G0-arrested, quiescent fibroblasts. In developing testicular germ cells, differential patterns of expression were seen for Nek1, Nek2 and Nek4, indicating possible overlapping, but non-identical functions.
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Specifications

Antigen NEK3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.52 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Nek3
Gene Accession No. P51956, Q9R0A5
Gene Alias glycogen synthase A kinase; HSPK 36; HSPK36; hydroxyalkyl-protein kinase; Nek3; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a)-related expressed kinase 3; NIMA (never in mitosis gene a)-related kinase 3; NIMA related kinase 3; NIMA-related expressed kinase 3; NIMA-related kinase 3; nimA-related protein kinase 3; phosphorylase B kinase kinase; serine/threonine-protein kinase Nek3
Gene Symbols Nek3
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 267-506 of human NEK3 (NP_689933.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23954, 306576, 4752
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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