Invitrogen™ NEU1 Polyclonal Antibody

Description

Immunogen sequence: PRKGRLIVCG HGTLERDGVF CLLSDDHGAS WRYGSGVSGI PYGQPKQEND FNPDECQPYE LPDGSVVINA RNQNNYHCHC RIVLRSYDAC DTLRPRDVTF DPELVDPVVA AGAVVTSSGI VFFSNPAHPE FRVNLTLRWS FSNGTSWRKE TVQLWPGPSG YSSLATLEGS MDGEEQAPQL YVLYEKGRNH YTESISVAKI SVYGTL Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasmic vesicle, Lumenal side, Lysosome lumen, Lysosome membrane, Peripheral membrane protein.

NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in NEU1 gene can lead to sialidosis.The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.