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Invitrogen™ Nicastrin Monoclonal Antibody (716918)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561548
This item is not returnable.
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Description
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
Specifications
| Nicastrin | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q92542 | |
| NCSTN | |
| Chinese hamster ovary cell line CHO-derived recombinant human Nicastrin, Asn34-Glu669. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Immunocytochemistry | |
| 716918 | |
| Unconjugated | |
| NCSTN | |
| 9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 23385 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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