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  5. Tocris Bioscience™ Nimbolide

Tocris Bioscience™ Nimbolide
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Product Code. 18745846
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25 mg
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18745846 25 mg 25mg
18765996 5 mg 5mg
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Product Code. 18745846 Supplier Tocris Bioscience™ Supplier No. 7289/25

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Description

RNF114 inhibitor

Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro. This compound impairs proliferation of triple-negative breast cancer cell lines. Nimbolide also induces apoptotic cell death in a Waldenströms macroglobulinemia cell line (BCWM1) and inhibits tumor growth in a xenograft model of Waldenströms macroglobulinemia.

Nimbolide can be used for the development of Degraders that utilize RNF114 as an E3 ligase for Targeted Protein Degradation.

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Specifications

Chemical Name or Material (2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
CAS 25990-37-8
Quantity 25 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C27H30O7
Purity 0.97
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