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Invitrogen™ Nodal Monoclonal Antibody (209009)
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Product Code. 30534202
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Quantity:
500 μg
Unit Size:
500µg
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Product Code. Quantity unitSize
30534202 500 μg 500µg
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Product Code. 30534202 Supplier Invitrogen™ Supplier No. MA560968

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Description

Rat Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nodal
Applications Western Blot
Classification Monoclonal
Clone 209009
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with trehalose and no preservative
Gene NODAL
Gene Accession No. P43021
Gene Alias early embryo mesoderm formation; HTX5; MGC138230; Nodal; nodal growth differentiation factor; nodal homolog; Tg.413d; transgenic lethal 413.d
Gene Symbols NODAL
Host Species Rat
Immunogen E. coli-derived recombinant mouse Nodal, His245-Leu354.
Purification Method Protein A/G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18119
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG1
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