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Invitrogen™ NOTCH1 Monoclonal Antibody (N253/32), PerCP
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA545606
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Description
1 μg/mL of MA5-45606 was sufficient for detection of Notch1 in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects >270kDa. Does not cross-react with Notch 2 or Notch3. This antibody was formerly sold as clone S253-32.
The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
Specifications
| NOTCH1 | |
| Monoclonal | |
| 1 mg/mL | |
| 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4 | |
| P46531, Q01705, Q07008 | |
| Notch1 | |
| Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Western Blot, Immunocytochemistry | |
| N253/32 | |
| PerCP | |
| Notch1 | |
| 9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1 | |
| Mouse | |
| Protein G | |
| RUO | |
| 18128, 25496, 4851 | |
| 4°C | |
| Liquid |
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