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Invitrogen™ NOTCH3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA519515
This item is not returnable.
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Description
Heat mediated antigen retrieval recommended prior to tissue staining.
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Specifications
| NOTCH3 | |
| Polyclonal | |
| Unconjugated | |
| Notch3 | |
| AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 18131, 4854, 56761 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry | |
| 0.9 mg/mL | |
| PBS with 0.02% sodium azide; pH 7.4 | |
| Q61982, Q9R172, Q9UM47 | |
| Notch3 | |
| Synthetic peptide conjugated to KLH derived from within residues 2300 to the C-terminus of Human NOTCH3. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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