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Invitrogen™ NOXA Polyclonal Antibody
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Product Code. 11528021
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
11528021 100 μg 100µg
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Product Code. 11528021 Supplier Invitrogen™ Supplier No. PA141010

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Description

Rabbit Polyclonal Antibody

Suggested positive control: human, mouse or rat thymus tissue lysate or protein, antigen standard for PMAIP1 (transient overexpression lysate). Immunogen sequence homology: amino acids 51-66: Rat (77%); amino acids 75-90: Rat (93%), Human (76%).

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
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Specifications

Antigen NOXA
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PMAIP1
Gene Accession No. Q13794, Q9JM54
Gene Alias adult T cell leukemia-derived PMA-responsive; APR; Immediate-early-response protein APR; Noxa; Phorbol-12-myristate-13-acetate-induced protein 1; PMA-ind; PMA-induced protein 1; Pmaip1; Protein Noxa
Gene Symbols PMAIP1
Host Species Rabbit
Immunogen Mixture of synthetic peptides containing amino acids 51-66 and 75-90 of mouse Noxa.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5366, 58801
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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