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NPS-2143, MedChemExpress

Product Code. 16455507
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Product Code. 16455507

Brand: Medchem Express HY10007

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Description

MedChemExpress NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

Specifications

Chemical Name or Material NPS-2143
CAS 284035-33-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C24H25ClN2O2
Quantity 5 mg
Synonym SB-262470A
Solubility Information DMSO : 17.86 mg/mL (43.68 mM; ultrasonic and adjust pH to 2 with H2O)
SMILES N#CC1=C(OC[C@@H](CNC(C)(CC2=CC=C3C=CC=CC3=C2)C)O)C=CC=C1Cl
Molecular Weight (g/mol) 408.92
Formula Weight 408.92
Percent Purity 98.09%
Grade Research
Physical Form Solid
For Use With (Application) Metabolism-protein/nucleotide metabolism
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Research purposes only

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