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Invitrogen™ NPTX2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA520521
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Description
A suggested positive control is mouse brain tissue lysate. PA5-20521 can be used with blocking peptide PEP-0641.
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
Specifications
| NPTX2 | |
| Polyclonal | |
| Unconjugated | |
| NPTX2 | |
| apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 288475, 4885, 53324 | |
| 4°C | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| O70340, P47972, P97738 | |
| NPTX2 | |
| A 16 amino acid peptide near the center of the human NPTX2. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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