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Invitrogen™ NR4A1 Polyclonal Antibody
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Product Code. 17129413
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Quantity:
100 μL
Unit Size:
100µL
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17129413 100 μL 100µL
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Product Code. 17129413 Supplier Invitrogen™ Supplier No. PA5111494

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PASASFKFED FQVYGCYPGP LSGPVDEALS SSGSDYYGSP CSAPSPSTPS FQPPQLSPWD GSFGHFSPSQ TYEGLRAWTE QLPKASG Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 92%.

NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NR4A1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NR4A1
Gene Accession No. P22736
Gene Alias early response protein NAK1; Gfrp; GFRP1; growth factor-inducible nuclear protein N10; Hbr1; Hbr-1; Hmr; hormone receptor; immediate early gene transcription factor NGFI-B; MGC9485; N10; NAK1; NAK-1; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; Ngfib; NGFI-B; NP10; Nr4a1; Nuclear hormone receptor NUR/77; nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; NUR77; Orphan nuclear receptor HMR; orphan nuclear receptor TR3; Orphan receptor tr3; ST-59; steroid receptor TR3; testicular receptor 3; TIS1; TR3; TR3 orphan receptor
Gene Symbols NR4A1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human NR4A1. Recombinant protein control fragment (Product #RP-105137).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3164
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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