Invitrogen™ NRCAM Polyclonal Antibody

Description

Positive Samples: SH-SY5Y, Mouse spinal cord, Mouse brain Immunogen sequence: QMISALEVPL DPKLLEDLVQ PPTITQQSPK DYIIDPRENI VIQCEAKGKP PPSFSWTRNG THFDIDKDPL VTMKPGTGTL IINIMSEGKA E.

Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.