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NRG1 Isoform 10 Polyclonal Antibody, Invitrogen™

Product Code. 15575031
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Quantity:
100 μg
Unit Size:
100µg
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15575031 100 μg 100µg
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Product Code. 15575031 Supplier Invitrogen Supplier No. PA538106

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Description

Rabbit Polyclonal Antibody

The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NRG1 Isoform 10
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NRG1
Gene Accession No. Q02297, P43322
Gene Alias Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; NRG1; GGF, HGL, HRGA, NDF, SMDF
Gene Symbols NRG1
Host Species Rabbit
Immunogen A synthetic peptide derived from human NRG1 isoform-10
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112400, 211323, 3084
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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