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Tocris Bioscience™ NS 8593 Hydrochloride
Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
Brand: Tocris Bioscience™ 4597/10
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Description
NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.Specifications
| NS 8593 hydrochloride | |
| N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride | |
| Soluble to 100mM in DMSO and to 20mM in ethanol | |
| Bioactive Small Molecule |
| 875755-24-1 | |
| 10 mg | |
| Solid |
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