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NSC 663284, MedChemExpress

Product Code. 16495497
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Product Code. 16495497

Brand: Medchem Express HY100034

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Description

MedChemExpress NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM).

NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM).

Specifications

Chemical Name or Material NSC 663284
Physical Form Solid
CAS 383907-43-5
Color Red
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C15H16ClN3O3
For Use With (Application) Cancer-programmed cell death
Synonym DA-3003-1
Solubility Information DMSO : ≥ 150 mg/mL (466.19 mM)
SMILES O=C(C(Cl)=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O
Molecular Weight (g/mol) 321.76
Formula Weight 321.76
Percent Purity 99.87%
Grade Research
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Research purposes only

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