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Invitrogen™ NTHL1 Recombinant Rabbit Monoclonal Antibody (8P6Z4)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA555507
This item is not returnable.
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Description
Immunogen Sequence: MCSPQESGMT ALSARMLTRS RSLGPGAGPR GCREEPGPLR RREAAAEARK SHSPVKRPRK AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD SSAPPKVRRY QVLLSL.
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
Specifications
| NTHL1 | |
| Recombinant Monoclonal | |
| 1.5 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P78549 | |
| NTHL1 | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human NTH1. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| ELISA, Western Blot | |
| 8P6Z4 | |
| Unconjugated | |
| NTHL1 | |
| bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; FAP3; hNTH1; nth (endonuclease III)-like 1 (E.coli); nth endonuclease III-like 1; Nth1; NTHL 1; Nthl1; nth-like DNA glycosylase 1; OCTS 3; OCTS3; thymine glycol DNA glycosylase/AP lyase | |
| Rabbit | |
| Protein A | |
| RUO | |
| 4913 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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