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Nutlin-3a, MedChemExpress

Product Code. 16405657
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Product Code. Quantity unitSize
16405657 5 mg 5mg
16489516 50 mg 50mg
16482908 10 mg 10mg
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Product Code. 16405657

Brand: Medchem Express HY10029

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Description

MedChemExpress Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.

Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.

Specifications

Chemical Name or Material Nutlin-3a
CAS 675576-98-4
Color White
Purity Grade Notes Research
Molecular Formula C30H30Cl2N4O4
Quantity 5 mg
Synonym Rebemadlin
Solubility Information DMSO : ≥ 100 mg/mL (171.97 mM)
SMILES O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H]([C@H]1C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
Molecular Weight (g/mol) 581.49
Formula Weight 581.49
Percent Purity 96.42%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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