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ON123300, MedChemExpress

Product Code. 16427987
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Product Code. 16427987

Brand: Medchem Express HY12624

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Description

MedChemExpress ON123300, a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. ON123300 inhibits CDK6 with an IC50 of 9.82 nM.

ON123300, a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. ON123300 inhibits CDK6 with an IC50 of 9.82 nM.

Specifications

Chemical Name or Material ON123300
Physical Form Solid
CAS 1357470-29-1
Color Orange
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C24H27N7O
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : 16.67 mg/mL (38.81 mM; ultrasonic and warming and heat to 60°C)
SMILES N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O
Molecular Weight (g/mol) 429.52
Formula Weight 429.52
Percent Purity 99.34%
Grade Research
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Research purposes only

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