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  6. OPA1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B2D8, Proteintech

OPA1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B2D8, Proteintech

Product Code. 16828595 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16828595 20 μL 20µL
16818595 150 μL 150µL
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Product Code. 16828595 Supplier Proteintech Supplier No. 665831IG20UL

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Description

Mouse Monoclonal Antibody

OPA1 is a dynamin-related GTPase that is critical for the maintece of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous domit trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.

Specifications

Antigen OPA1
Applications Western Blot
Classification Monoclonal
Clone 1B2D8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene OPA1
Gene Accession No. O60313, P58281, Q2TA68
Gene Alias KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1
Gene Symbols Opa1
Host Species Mouse
Immunogen OPA1 Fusion Protein Ag26868
Purification Method Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100522705, 171116, 4976, 74143
Target Species Mouse, Pig, Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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