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OTUD7B Monoclonal Antibody (OTI3D10), TrueMAB™, OriGene

Product Code. 17551834
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100 μL
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17551834 100 μL 100µL
17571834 30 μL 30µL
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Product Code. 17551834 Supplier Origene Technologies Supplier No. TA809517

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Description

Mouse Monoclonal Antibody

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ′Lys-48′-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ′Lys-11′, ′Lys-48′ or ′Lys-63′- linked polyubiquitin chains. In vitro, has preference for ′Lys- 11′-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Specifications

Antigen OTUD7B
Applications Western Blot
Classification Monoclonal
Clone OTI3D10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene OTUD7B
Gene Accession No. Q6GQQ9
Gene Alias CEZANNE, ZA20D1
Gene Symbols OTUD7B
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 449-729 of human OTUD7B produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56957
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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