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Invitrogen™ p19ARF Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA130670
This item is not returnable.
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Description
PA1-30670 recognizes p19ARF, Uniprot ID Q64364. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
Specifications
| p19ARF | |
| Polyclonal | |
| Unconjugated | |
| Cdkn2a | |
| Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; INK4; INK4A; Ink4a/Arf; INK4a-ARF; LOC100764983; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16INK4A; p16-INK4a; P19; p19>ARF>; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 12578, 25163 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 1 mg/mL | |
| Tris citrate, tris phosphate with 0.1% sodium azide; pH 7.0-8.0 | |
| Q64364, Q8QZZ9 | |
| Cdkn2a | |
| Synthetic peptide conjugated to KLH, derived from a sequence within residues 50-150 of mouse p19ARF.. | |
| 100 μL | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG |
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