Invitrogen™ p27 Kip1 Monoclonal Antibody (3D8)

Description

MA5-15635 targets CDKN1B in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15635 immunogen is purified recombinant fragment of human CDKN1B expressed in E. Coli. MA5-15635 detects CDKN1B which has a predicted molecular weight of approximately 22kDa.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.