missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ p27 Kip1 Recombinant Rabbit Monoclonal Antibody (23GB1825), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA554152
This item is not returnable.
View return policy
Description
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Specifications
| p27 Kip1 | |
| Recombinant Monoclonal | |
| Unconjugated | |
| Cdkn1b | |
| AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 1027, 83571 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 23GB1825 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P46527 | |
| Cdkn1b | |
| A synthesized peptide derived from human p27 KIP 1 (150-198AA). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction