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Invitrogen™ PABPC4 Polyclonal Antibody
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Product Code. 15958744
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Quantity:
100 μL
Unit Size:
100µL
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15958744 100 μL 100µL
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Product Code. 15958744 Supplier Invitrogen™ Supplier No. PA566018

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QYMQRVAGMRA LPANAILNQF QPAAGGYFVP AVPQAQGRPP YYTPNQLAQM RPNP Highest antigen sequence identity to the following orthologs - mouse 98%, rat 100%.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PABPC4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PABPC4
Gene Accession No. Q13310
Gene Alias Activated-platelet protein 1; APP1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP4; PABP-4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4
Gene Symbols PABPC4
Host Species Rabbit
Immunogen Recombinant Human PABPC4. Recombinant protein control fragment (Product #RP-105047).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8761
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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