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Invitrogen™ PAK4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5120128
This item is not returnable.
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Description
Positive test controls include: LNCaP, Mouse testis, Mouse brain. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: HDGRVKLSDF GFCAQVSKEV PRRKSLVGTP YWMAPELISR LPYGPEVDIW SLGIMVIEMV DGEPPYFNEP PLKAMKMIRD NLPPRLKNLH KVSPSLKGFL D.
PAK4 is a serine/ threonine p21 activating kinase implicated in the reorganization of actin cytoskeleton and in the formation of filopodia. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. The second group includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK4 was initially identified as a novel effector of Cdc42Hs. Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization, showing that it is involved in cytoskeletal reorganization. Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development. PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways.
Specifications
| PAK4 | |
| Polyclonal | |
| Unconjugated | |
| Pak4 | |
| 5730488L07Rik; AW555722; hypothetical protein LOC431769; im:5916170; Kiaa1142; mKIAA1142; p21 (CDKN1A)-activated kinase 4; p21 (RAC1) activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; Pak4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4; wu:fd12b01; zgc:92014 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 70584 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 2.65 mg/mL | |
| PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
| Q8BTW9 | |
| Pak4 | |
| A synthetic peptide corresponding to a sequence within amino acids 450-550 of human PAK4 (NP_005875.1). | |
| 100 μL | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG |
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