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Invitrogen™ PALB2 Polyclonal Antibody
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Product Code. 15988774
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
15988774 100 μL 100µL
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Product Code. 15988774 Supplier Invitrogen™ Supplier No. PA566053

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YDKLHIKTHLD EETGEKTSIT LDVGPESFNP GDGPGGLPIQ RTDDTQEHFP HRVSDPSGEQ KQKLPSRRKK QQKRTFISQE RDCVFGTDSL Highest antigen sequence identity to the following orthologs - mouse 39%, rat 41%.

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PALB2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Palb2
Gene Accession No. Q86YC2
Gene Alias BC066140; FANCN; FLJ21816; PALB2; Partner and localizer of BRCA2; PNCA3; RGD1304759
Gene Symbols Palb2
Host Species Rabbit
Immunogen Recombinant Human PALB2. Recombinant protein control fragment (Product #RP-106745).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79728
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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