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PAP-1, MedChemExpress

Product Code. 16494236
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Product Code. 16494236

Brand: Medchem Express HY10015

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Description

MedChemExpress PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects.

PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects.

Specifications

Chemical Name or Material PAP-1
CAS 870653-45-5
Color White
Purity Grade Notes Research
Molecular Formula C21H18O5
Quantity 100 mg
Synonym 5-(4-Phenoxybutoxy)psoralen
Solubility Information DMSO : 50 mg/mL (142.71 mM; Need ultrasonic)
SMILES O=C1C=CC(C(O1)=CC2=C3C=CO2)=C3OCCCCOC4=CC=CC=C4
Molecular Weight (g/mol) 350.36
Formula Weight 350.36
Percent Purity 98.75%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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