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Invitrogen™ PARP12 Polyclonal Antibody
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Product Code. 16557521
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Quantity:
100 μL
Unit Size:
100µL
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16557521 100 μL 100µL
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Product Code. 16557521 Supplier Invitrogen™ Supplier No. PA589749

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YVSPQDVTTM QTCNTKFPGP KSIPDYWDSS ALPDPGFQKI TLSSSSEEYQ KVWNLFNRTL PFYFVQKIER VQNLALWEVY QWQKGQMQKQ NGGKAVDERQ LFHGTSAIFV DAICQQNFDW RVCGVHGTSY GKGSYFARDA AYSHHYSKSD TQTHTMFLAR VLVGEFVRGN ASFVRPPAKE GWSNAFYDSC VNSVSDPSIF VIFEKHQVYP EYVIQYTTSS KPSVTPSILL ALGSLFSSRQ; Positive Samples: HT-29, HeLa, Mouse brain, Mouse liver, Mouse pancreas, Rat brain; Cellular Location: Nucleus.

Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PARP12
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.84 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PARP12
Gene Accession No. Q8BZ20, Q9H0J9
Gene Alias 9930021O16; AA409132; AA536654; ADP-ribosyltransferase diphtheria toxin-like 12; ARTD12; MST109; MSTP109; PARP12; PARP-12; poly (ADP-ribose) polymerase family, member 12; poly [ADP-ribose] polymerase 12; poly ADP-ribose polymerase 12; poly(ADP-ribose) polymerase family member 12; Protein mono-ADP-ribosyltransferase PARP12; ZC3H1; Zc3hdc1; Zinc finger CCCH domain-containing protein 1; zinc finger CCCH type domain containing 1
Gene Symbols PARP12
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 243771, 362343, 64761
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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