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DiscoverX PathHunter™ eXpress ACVRL1/ACVR2 Dimerization Assay

Product Code. 17304109
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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Product Code. 17304109

Brand: DiscoverX 930963E3CP0L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress ACVRL1/ACVR2 Dimerization Assay measures ligand-induced dimerization of ACVRL1/ACVR2 . eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ ACVRL1/ACVR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR2 target protein fused to PK alongside ACVRL1 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2 , detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry ACVRL1/ACVR2 Dimerization
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist GDF-2
Quantity 1,000 dp (10 x 96-well)
Target Entry ACVRL1/ACVR2
Cell Line U2OS
Target ACVRL1/ACVR2
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