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DiscoverX PathHunter™ eXpress EpoR-JAK2 Functional Assay

Product Code. 17343979
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
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17343979 1,000 dp (10 x 96-well) 1 set
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Product Code. 17343979 Supplier DiscoverX Supplier No. 930900E3CP16L

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Description

The PathHunter™ eXpress EpoR-JAK2 Functional Assay measures EpoR cytokine receptor activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ EpoR-JAK2 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses EpoR activation via detection of JAK2 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged EpoR cytokine receptor, an untagged CTK JAK2 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Receptor Phosphorylation
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Erythropoietin
Quantity 1,000 dp (10 x 96-well)
Target Entry EpoR-JAK2
Cell Line U2OS
Target EpoR-JAK2
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