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DiscoverX PathHunter™ eXpress mEBI2 CHO-K1 β-Arrestin GPCR Assay

Product Code. 17354079
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17354079

Brand: DiscoverX 930953E2MCP0L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress mEBI2 CHO-K1 β-Arrestin GPCR Assay measures mEBI2 (GPCR) activity via recruitment of β-Arrestin2. eXpress kits contain all assay materials: cells, reagents, and plates. Mouse version.

The PathHunter™ mEBI2 β-Arrestin eXpress Kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. dihydroxycholesterol) based activation of mEBI2 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cells overexpress PK-tagged mEBI2 and EA-tagged β-Arrestin 2. Activation of mEBI2 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein.

Specifications

Assay Entry β-Arrestin-2 recruitment
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist 7α,25-dihydroxycholesterol
Quantity 1,000 dp (10 x 96-well)
Target Entry mEBI2
Cell Line CHO-K1
Target mEBI2
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