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DiscoverX PathHunter™ eXpress mINSRa Functional Assay

Product Code. 17394229
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17394229

Brand: DiscoverX 931015E3CP16L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress mINSRa Functional Assay measures mINSRa receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates. Mouse version.

The PathHunter™ eXpress mINSRa Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated mINSRa dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged mINSRa and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the mouse version of the protein.

Specifications

Assay Entry Receptor Phosphorylation
For Use With (Application) Assay-Ready eXpress Kits
Primary Agonist Insulin, Human
Quantity 1,000 dp (10 x 96-well)
Target Entry mINSRa
Cell Line U2OS
Target mINSRa
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