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DiscoverX PathHunter™ eXpress TrkB-P75 Functional Assay

Product Code. 17333349
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17333349

Brand: DiscoverX 930530E3CP16L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress TrkB-P75 Functional Assay measures TrkB-P75 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates.

The PathHunter™ eXpress TrkB-P75 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated TrkB and P75 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged TrkB and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, P75 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Specifications

Assay Entry Kinase
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry TrkB-P75
Target TrkB-P75
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