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DiscoverX PathHunter™ HEK 293 cyno CXCR1 β-Arrestin Cell Line

Product Code. 17384139
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17384139

Brand: DiscoverX 930980C1

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This item is not returnable. View return policy

Description

The PathHunter™ HEK 293 cyno CXCR1 β-Arrestin Cell Line measures CXCR1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Cyno protein.

The PathHunter™ cyno CXCR1 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged cyno CXCR1 and EA-tagged β-Arrestin 2. Activation of CXCR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry β-Arrestin Recruitment
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist Recombinant Human IL-8 (CXCL8)
Quantity 2 Vials
Target Entry cyno CXCR1
Accession Number EHH55157
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